The Department’s research projects cover molecular pharmacology, drug metabolism, natural compounds and disease mechanisms.
Project in progress
NCN OPUS-23 — 2022/45/B/NZ7/01056
Project: Searching for natural bioactive farnesoid X receptor agonists and their role in parenteral nutrition-associated liver disease: in silico, in vitro and in vivo studies.
Period: Jan 10, 2023–Jan 9, 2027 (48 months).
Principal investigator: dr hab. Maciej Jan Stawny.
Host institution: Poznan University of Medical Sciences; Chair and Department of Pharmaceutical Chemistry.
Funding: PLN 3,985,130.
Completed and earlier projects
MNiSW/KBN — N40502331/1522
Project: Effect of plant-derived substances on the activity of cytochrome P450 drug-metabolizing enzymes.
Period: 2005–2008.
Principal investigator: doc. dr hab. P.M. Mrozikiewicz.
Host institution: Institute of Natural Fibres and Medicinal Plants, Poznań.
MNiSW/KBN — 2P05F03228
Project: Increasing the production of secondary metabolites with central nervous system-stimulating activity in in vitro bioreactor cultures of roseroot (Rhodiola rosea L.).
Period: 2005–2008.
Principal investigator: dr A. Krajewska-Patan.
Host institution: Institute of Natural Fibres and Medicinal Plants, Poznań.
MNiSW/KBN — N40502432/1684
Project: Role of endogenous opioids in the central mechanism of the anti-alcohol effects of Pueraria lobata (kudzu).
Period: 2007–2009.
Principal investigator: prof. UM dr hab. Przemysław Mikołajczak.
Host institution: Chair and Department of Pharmacology, Poznan University of Medical Sciences.
MNiSW/KBN — N40502532/1687
Project: Secondary metabolites of Rhodiola kirilowii in in vitro culture and field cultivation: active compounds and biological activity related to hypoxia.
Period: 2007–2011.
Principal investigator: dr A. Krajewska-Patan.
Host institution: Institute of Natural Fibres and Medicinal Plants, Poznań.
MNiSW/KBN — N405101934
Project: Effects of Epilobium angustifolium and Serenoa repens extracts on gene expression associated with benign prostatic hyperplasia.
Period: 2008–2010.
Principal investigator: doc. dr hab. P.M. Mrozikiewicz.
Host institution: Institute of Natural Fibres and Medicinal Plants, Poznań.
MNiSW/KBN — N405417836
Project: Medicinal plants of the Lamiaceae family in Alzheimer’s disease: model studies.
Period: 2008–2011.
Principal investigator: dr hab. Marcin Ożarowski.
Host institution: Institute of Natural Fibres and Medicinal Plants, Poznań.
MNiSW/KBN — N405358737
Project: Role of ghrelin in assessing the efficacy of anti-alcohol agents.
Period: 2009–2011.
Principal investigator: dr Michał Szulc.
Host institution: Chair and Department of Pharmacology, Poznan University of Medical Sciences.
MNiSW/KBN — N402357638
Project: Selected non-classical proatherogenic factors in people with type 2 diabetes in relation to pharmacotherapy.
Period: 2010–2012.
Principal investigator: dr Magdalena Borowska.
Host institution: Chair and Department of Pharmacology, Poznan University of Medical Sciences.
NCN — N405677140
Project: Effects of plant-derived substances and synthetic drugs on MDR1, MRP1, MRP2 and OATP-family genes involved in blood–brain barrier activity.
Period: 2011–2013.
Principal investigator: prof. dr hab. P.M. Mrozikiewicz.
Host institution: Department of Clinical Pharmacy and Biopharmacy, Poznan University of Medical Sciences.
MNiSW/KBN/NCN — N405219539
Project: Preparation and phytochemical analysis of Platycodon grandiflorum extracts and assessment of their effects on factors associated with chronic bronchitis in rats.
Period: 2010–2013.
Principal investigator: prof. IWNIRZ dr hab. W. Buchwald.
Host institution: Institute of Natural Fibres and Medicinal Plants, Poznań.
MNiSW/KBN/NCN — N405677740
Project: Biological and pharmacological studies of protein and non-protein fractions of Chelidonium majus extracts from field-grown and in vitro plant material.
Period: 2011–2014.
Principal investigator: prof. IWNiRZ dr hab. B. Kędzia.
Host institution: Institute of Natural Fibres and Medicinal Plants, Poznań.
MNiSW — NN405 678040
Project: Comparative study of the anti-alcohol activity of Salvia miltiorrhiza and Salvia przewalskii extracts from field and in vitro cultivation.
Period: 2011–2014.
Principal investigator: prof. dr hab. Przemysław Mikołajczak.
Host institution: Institute of Natural Fibres and Medicinal Plants, Poznań.
NCBR INNOMED — I/11/NCBR/2014 (Onkokan)
Project: Development of a technology for obtaining low-THC hemp cannabinoids to support the treatment of oncology patients.
Period: 2014–2018.
Principal investigator: prof. dr hab. Ryszard Słomski.
Host institution: Poznań University of Life Sciences.
NCN Miniatura 1 — 2017/01/X/NZ7/02041
Project: Cannabidiol as a modulator of alcohol tolerance development in rats: in vivo molecular mechanisms.
Period: 2018.
Principal investigator: dr Michał Szulc.
Host institution: Chair and Department of Pharmacology, Poznan University of Medical Sciences.
NCN OPUS 13 — 2017/25/B/NZ7/02741
Project: Role of flavonoids in pregnancy-induced hypertension: in vitro and in vivo studies.
Period: Feb 22, 2018–Feb 21, 2021.
Principal investigator: prof. dr hab. Agnieszka Seremak-Mrozikiewicz.
Host institution: Institute of Natural Fibres and Medicinal Plants.
Funding: 864 947 zł.
Projekt wewnętrzny Katedry i Zakładu Farmakologii
Project: Changes in expression of genes encoding selected phase II xenobiotic metabolism enzymes in the livers of rats with induced alcohol tolerance.
Period: October–December 2021.
Host institution: Poznan University of Medical Sciences Core Facility.