SCIENTIFIC PROFILE OF THE PHARMACOLOGY DEPARTMENT - MAIN RESEARCH TOPICS
1. Studies on active substances (newly synthesized chemical compounds, their natural derivatives and plant raw materials) with activities affecting the functions of the central nervous system, in particular with potential anti-alcohol properties.
2. The use of modern molecular techniques and behavioral analyzes on laboratory animals in experimental pharmacology.
3. Studies on the explanation of pathogenesis and the search for a potential pharmacological point in the therapy of depression and concomitant diabetes, pathomechanisms for the development of chronic complications of this disease, especially macroangiopathy and atherosclerosis - analysis of the interaction of selected proteins involved in the mechanism of postreceptor dysregulation of the signaling cascades in the process of co-occurrence of these diseases - i.e. role of insulin receptor, metalloproteinases, adropine, IRS-1 and IRS-2, PI3K kinases, etc.
4. In vitro studies on the antitumor properties of newly synthesized molecules, in particular pyrimidine and purine nucleoside derivatives, large steroidal molecules, conjugates and their natural derivatives.
5. Early in vitro screening studies in the CNS Drug Discovery strategy - in the field of predicting the penetration of new chemical molecules through the blood-brain barrier (using i.e. the MDCK-MDR1 bi-directional assay).
6. Research on the efficacy and safety of pharmacotherapy of thyroid disorders, in particular their mild forms.
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